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Monitor Carefully (one)mitotane decreases levels of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Monitor. Mitotane is often a strong inducer of cytochrome P-4503A4; observe when coadministered with CYP3A4 substrates for achievable dosage changes.Benzodiazepines are good allosteric modulators in the GABA sort A rece